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Carboxylation of Hydroxyaromatic Compounds with HCO3− by Enzyme Catalysis: Recent Advances Open the Perspective for Valorization of Lignin-Derived Aromatics.

Authors :
Tommasi, Immacolata C.
Source :
Catalysts (2073-4344); Jan2019, Vol. 9 Issue 1, p37-1, 1p
Publication Year :
2019

Abstract

This review focuses on recent advances in the field of enzymatic carboxylation reactions of hydroxyaromatic compounds using HCO<subscript>3</subscript><superscript>−</superscript> (as a CO<subscript>2</subscript> source) to produce hydroxybenzoic and other phenolic acids in mild conditions with high selectivity and moderate to excellent yield. Nature offers an extensive portfolio of enzymes catalysing reversible decarboxylation of hydroxyaromatic acids, whose equilibrium can be pushed towards the side of the carboxylated products. Extensive structural and mutagenesis studies have allowed recent advances in the understanding of the reaction mechanism of decarboxylase enzymes, ultimately enabling an improved yield and expansion of the scope of the reaction. The topic is of particular relevance today as the scope of the carboxylation reactions can be extended to include lignin-related compounds in view of developing lignin biorefinery technology. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734344
Volume :
9
Issue :
1
Database :
Complementary Index
Journal :
Catalysts (2073-4344)
Publication Type :
Academic Journal
Accession number :
134358009
Full Text :
https://doi.org/10.3390/catal9010037