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One method to establish Epstein‐Barr virus‐associated NK/T cell lymphoma mouse models.
- Source :
- Journal of Cellular & Molecular Medicine; Feb2019, Vol. 23 Issue 2, p1509-1516, 8p
- Publication Year :
- 2019
-
Abstract
- Novel nude mice model of human NK/T cell lymphoma were established by subcutaneously injecting two NK/T cell lymphoma cell lines into the right axillary region of mice and successful passages were completed by injecting cell suspension which was obtained through a 70‐μm cell strainer. These mice models and corresponding cell clones have been successfully developed for more than 8 generations. The survival rates of both resuscitation and transplantation in NKYS and YT models were 90% and 70% correspondingly. Pathologically, the tumour cells in all passages of the lymphoma‐bearing mice and cell lines obtained from tumours were parallel to initial cell lines. Immunologically, the tumour cells expressed the characteristics of the primary and essential NK/T lymphomas. The novel mice models maintained the essential features of human NK/T cell lymphoma, and they would be ideal tools in vivo for further research of human NK/T cell lymphoma. [ABSTRACT FROM AUTHOR]
- Subjects :
- T-cell lymphoma
KILLER cells
EPSTEIN-Barr virus
CANCER chemotherapy
APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 15821838
- Volume :
- 23
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Cellular & Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 134323819
- Full Text :
- https://doi.org/10.1111/jcmm.14057