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Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS.
- Source :
- PLoS ONE; 1/14/2019, Vol. 14 Issue 1, p1-16, 16p
- Publication Year :
- 2019
-
Abstract
- Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ALS, we studied the effect of known stem cell mobilizing agents (treatment) and antimetabolite 5-fluorouracil (5-FU) (anti-treatment) in SOD1G93A model of ALS. Surprisingly, we found that anti-cancer drug 5-FU increases lifespan, delays the disease onset and improves motor performance in ALS mice. Although we were not able to demonstrate the mechanistic basis of the beneficial 5-FU action in ALS mice, our findings suggest that 5-FU or similar drugs are possible drug candidates for the treatment of motor neuron diseases through drug repurposing. [ABSTRACT FROM AUTHOR]
- Subjects :
- FLUOROURACIL
MICE
ANTINEOPLASTIC agents
MURIDAE
NEURONS
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 134109134
- Full Text :
- https://doi.org/10.1371/journal.pone.0210752