Back to Search
Start Over
Systematic review of efficacy and safety of lamotrigine in the treatment of juvenile myoclonic epilepsy.
- Source :
- Chinese Journal of Contemporary Neurology & Neurosurgery; Oct2018, Vol. 18 Issue 10, p740-746, 7p
- Publication Year :
- 2018
-
Abstract
- Objective To evaluate the efficacy and safety of lamotrigine in the treatment of juvenile myoclonic epilepsy (JME). Methods Retrieve relevant clinical guidelines, systematic review (including Meta - analysis), randomized controlled clinical trials, case - control studies, retrospective cohort studies and case observation studies on lamotrigine treating JME from online databases (January 1, 1980-December 31, 2017) as PubMed, EBMASE/SCOPUS and Cochrane Library with key words: juvenile myoclonic epilepsy, idiopathic generalized epilepsies, lamotrigine, antiepileptic drugs, random. Jadad Scale, Cochrane System Evaluation Handbook and RevMan 5.3 statistical software were used for quality assessment and Meta-analysis. Results The research enrolled 1220 articles, from which 6 studies with Jadad score ≥ 4 (4 randomized controlled clinical trials and 2 case observation studies) were chosen after excluding duplicates and those not meeting the inclusion criteria. A total of 314 JME patients (166 cases treated by lamotrigine and 148 cases treated by valproate) were enrolled in 6 studies. Meta-analysis showed the occurrence rate of adverse reaction in lamotrigine group was significantly lower than that in valproate group (RR = 0.540, 95% CI: 0.320-0.910; P = 0.020), but there was no significant difference on rate of epileptic seizures decreasing > 50% (RR = 1.200, 95% CI: 0.870-1.650; P = 0.260). Conclusions Lamotrigine is safe and effective in the treatment of JME. It has better tolerance and less adverse reaction, and its effect is similar to that of valproate. It is the first choice for patients with JME, especially for adolescent female patients with JME. However, there is still lack of high-quality trials to confirm whether the combination with other drugs has any benefit in terms of efficacy. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTICONVULSANTS
COMBINATION drug therapy
CONFIDENCE intervals
EPILEPSY
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL information storage & retrieval systems
LONGITUDINAL method
META-analysis
SCIENTIFIC observation
QUALITY assurance
INFANTILE spasms
VALPROIC acid
LAMOTRIGINE
SYSTEMATIC reviews
TREATMENT effectiveness
RETROSPECTIVE studies
CASE-control method
DATA analysis software
ODDS ratio
THERAPEUTICS
Subjects
Details
- Language :
- Chinese
- ISSN :
- 16726731
- Volume :
- 18
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Chinese Journal of Contemporary Neurology & Neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 133968857
- Full Text :
- https://doi.org/10.3969/j.issn.1672-6731.2018.10.010