Back to Search Start Over

Toll-like receptor 4 in acute viral infection: Too much of a good thing.

Authors :
Olejnik, Judith
Hume, Adam J.
Mühlberger, Elke
Source :
PLoS Pathogens; 12/20/2018, Vol. 14 Issue 12, p1-7, 7p
Publication Year :
2018

Abstract

The article examines the role of toll-like receptor 4 (TLR4) in damaging inflammatory responses during acute viral infections. Topics discussed include the ligands of TLR4, activation of viruses that induce an inflammatory response during acute infection through TLR4, and the therapeutic potential of TLR4. The role of over-stimulation of TLR4 in excessive inflammatory response that is damaging to the host and its benefits to the host by establishing a protective immune response are explained.

Details

Language :
English
ISSN :
15537366
Volume :
14
Issue :
12
Database :
Complementary Index
Journal :
PLoS Pathogens
Publication Type :
Academic Journal
Accession number :
133661485
Full Text :
https://doi.org/10.1371/journal.ppat.1007390