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Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors.
- Source :
- Acta Oncologica; Oct2018, Vol. 57 Issue 10, p1392-1400, 9p, 1 Diagram, 3 Charts, 3 Graphs
- Publication Year :
- 2018
-
Abstract
- Background: The long-term toxicities after cisplatin-based chemotherapy (CBCT) reveal a remarkable inter-individual variation among testicular cancer survivors (TCSs). Therefore, we assessed long-term platinum (Pt) changes and their associations with CBCT-related late effects in TCSs. Material and methods: In 77 TCSs treated with CBCT from 1984 to 1990, blood samples for analyses of Pt and a questionnaire including self-reported neuro- and ototoxicity (NTX) symptoms were collected during two follow-up surveys at median 12 (Survey I; SI) and 20 (Survey II; SII) years after treatment. Information about second cancers after SII was retrieved from the Norwegian Cancer Registry. Results: A larger Pt decline from SI to SII was associated with a decreased risk of a second cancer diagnosis (HR 0.78, 95% CI 0.62-0.99 per 10 ng/L/year), and worsening of paresthesias in hands (OR 1.98, 95% CI 1.09-3.59 per 10 ng/L/year) and tinnitus (OR 1.51, 95% CI 1.01-2.27 per 10 ng/L/year). Conclusion: In summary, we found a significant association between a larger Pt decline and a reduced risk of second cancers and deterioration of paresthesias in hands and tinnitus. [ABSTRACT FROM AUTHOR]
- Subjects :
- TINNITUS
PARESTHESIA
CANCER chemotherapy
CANCER patients
SECONDARY primary cancer
CISPLATIN
CONFIDENCE intervals
REPORTING of diseases
HAND
PLATINUM
QUESTIONNAIRES
SELF-evaluation
SURVEYS
TESTIS tumors
THERAPEUTIC complications
OTOTOXICITY
ODDS ratio
PREVENTION
DIAGNOSIS
DISEASE risk factors
TUMOR risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 0284186X
- Volume :
- 57
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Acta Oncologica
- Publication Type :
- Academic Journal
- Accession number :
- 133262859
- Full Text :
- https://doi.org/10.1080/0284186X.2018.1473641