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Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms.
- Source :
- Journal of Infectious Diseases; 2018 Supplement, Vol. 218, pS553-S564, 12p
- Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>Several vaccine platforms have been successfully evaluated for prevention of Ebola virus (EBOV) disease (EVD) in nonhuman primates and humans. Despite remarkable efficacy by multiple vaccines, the immunological correlates of protection against EVD are incompletely understood.<bold>Methods: </bold>We systematically evaluated the antibody response to various EBOV proteins in 79 nonhuman primates vaccinated with various EBOV vaccine platforms. We evaluated the serum immunoglobulin (Ig)G titers against EBOV glycoprotein (GP), the ability of the vaccine-induced antibodies to bind GP at acidic pH or to displace ZMapp, and virus neutralization titers. The correlation of these outcomes with survival from EVD was evaluated by appropriate statistical methods.<bold>Results: </bold>Irrespective of the vaccine platform, protection from EVD strongly correlated with anti-GP IgG titers. The GP-directed antibody levels required for protection in animals vaccinated with virus-like particles (VLPs) lacking nucleoprotein (NP) was significantly higher than animals immunized with NP-containing VLPs or adenovirus-expressed GP, platforms that induce strong T-cell responses. Furthermore, protective immune responses correlated with anti-GP antibody binding strength at acidic pH, neutralization of GP-expressing pseudovirions, and the ability to displace ZMapp components from GP.<bold>Conclusions: </bold>These findings suggest key quantitative and qualitative attributes of antibody response to EVD vaccines as potential correlates of protection. [ABSTRACT FROM AUTHOR]
- Subjects :
- EBOLA virus disease prevention
IMMUNOGLOBULIN G
VIRION
EBOLA virus disease vaccines
GLYCOPROTEINS
ANIMAL experimentation
COMPARATIVE studies
EBOLA virus disease
HYDROGEN-ion concentration
IMMUNIZATION
RESEARCH methodology
MEDICAL cooperation
PRIMATES
PROTEINS
RESEARCH
VIRAL antibodies
VIRAL vaccines
VIRUSES
EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 218
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 133211518
- Full Text :
- https://doi.org/10.1093/infdis/jiy316