Determination of Three Kinds of Polyether Drug Residues in Eggs by QuEChERS dSPE EMR-Lipid-LC/MS/MS.

[Objectives] This study was conducted to establish an LC-MS/VIS method for the determination of three kinds of polyether residues in eggs with QuEChERS dSPE EMR-Lipid as a pretreatment method, which was established according to Agilent Bond Elut enhanced lipid removal EMR-Iipid technology. [Methods] Egg was extracted by acidified acetonitrile, purified by Bond Elut EMR-Iipid QuEChERS, and detected by HPLC-MS/MS. [Results] The three kinds of polyether residues had good linear relationships in the range of 2.0 - 100 p.g/L with peak areas, r > 0.999. The recoveries ranged from 84.6% to 107.0%. [ Conclusions] The method is convenient and accurate, and the quantitative results are accurate and reproducible. It is suitable for the determination of the three kinds of polyether residues in eggs. [ABSTRACT FROM AUTHOR]