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HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients.

Authors :
Triantafyllidi, Helen
Benas, Dimitris
Vlachos, Stefanos
Vlastos, Dimitris
Pavlidis, George
Schoinas, Antonios
Varoudi, Mary
Birmpa, Dionysia
Moutsatsou, Paraskevi
Lekakis, John
Ikonomidis, Ignatios
Source :
Journal of Clinical Hypertension; Nov2018, Vol. 20 Issue 11, p1615-1623, 9p
Publication Year :
2018

Abstract

Endothelial dysfunction indicates target organ damage in hypertensive patients. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity, and finally to cardiovascular disease. The authors aimed to investigate the role of increased HDL cholesterol (HDL-C) levels, which usually are considered protective against cardiovascular disease, in EG integrity in older hypertensive patients. The authors studied 120 treated hypertensive patients older than 50 years were divided regarding HDL-C tertiles in group HDLH (HDL-C ≥ 71 mg/dL, upper HDL-C tertile) and group HDLL (HDL-C < 71 mg/dL, two lower HDL-C tertiles). Increased perfusion boundary region (PBR) of the sublingual arterial microvessels (ranging from 5 to 9 µm) using Sideview Darkfield imaging (Microscan, Glycocheck) was measured as a non-invasive accurate index of reduced EG thickness. PBR 5-9 was significantly decreased in group HDLH (P = 0.04). In the whole population, HDL-C was inversely but moderately related to PBR 5-9 (r = -0.22, P = 0.01). In a multiple linear regression analysis model, using age, BMI, smoking habit, HDL-C, LDL-C, and office SBP, as independent variables, the authors found that BMI (β = 0.25, P = 0.006) independently predicted PBR 5-9 in the whole population. In older hypertensive patients, HDL-C ranging between 71 and 101 mg/dL might moderately protect EG and subsequently endothelial function. Future studies in several groups of low- or high-risk hypertensives are needed in order to evaluate the beneficial role of extremely elevated HDL-C regarding cardiovascular risk evaluation as well as endothelial glycocalyx as a novel index of target organ damage in essential hypertension. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15246175
Volume :
20
Issue :
11
Database :
Complementary Index
Journal :
Journal of Clinical Hypertension
Publication Type :
Academic Journal
Accession number :
132916321
Full Text :
https://doi.org/10.1111/jch.13404