Electrochemical Synthesis of 3,5‐Disubstituted‐1,2,4‐thiadiazoles through NH4I‐Mediated Dimerization of Thioamides.

A electrochemical method for the synthesis of 3,5‐disubstituted‐1,2,4‐thiadiazoles through NH4I‐mediated dimerization of thioamides is reported. Using the inexpensive NH4I as electrolyte and catalyst, this electrosynthesis approach requires no oxidizing agents and enables the convenient production of diverse 1,2,4‐thiadiazoles products. The approach is an example of S−N bond construction through the electrochemical method. [ABSTRACT FROM AUTHOR]