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The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice

The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice

Authors :
Orlova, M. A.
Trofimova, T. P.
Aleshin, G. Yu.
Belyshev, S. S.
Orlov, A. P.
Source :
Russian Chemical Bulletin; Aug2018, Vol. 67 Issue 8, p1542-1543, 2p
Publication Year :
2018

Abstract

The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide <superscript>69m</superscript>Zn in the organs of mice and its rate of excretion were studied. A solution of ZnCl<subscript>2</subscript> was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10665285
Volume :
67
Issue :
8
Database :
Complementary Index
Journal :
Russian Chemical Bulletin
Publication Type :
Academic Journal
Accession number :
132729519
Full Text :
https://doi.org/10.1007/s11172-018-2254-9