Front Cover: Direct Synthesis of 2‐Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti‐Inflammatory Activity (Asian J. Org. Chem. 10/2018).

2‐Acyl acridines were synthesized through rhodium(III)‐catalyzed C−H aminations of aldimines with anthranils followed by intramolecular cyclization. All synthesized 2‐acyl acridines were first screened for cytotoxic activity against human renal carcinoma cells (CAKI‐1 and 786‐O) and human breast carcinoma cells (MCF‐7). In addition, compounds that exhibited potent cytotoxicities were selected for further in vitro anti‐inflammatory activity testing using interleukin‐6 (IL‐6) with lipopolysaccharide (LPS)‐induced RAW264.7 cells. More information can be found in the Full Paper by Hyung Sik Kim, Jin‐Mo Ku, In Su Kim et al. on page 2069 in Issue 10, 2018 (DOI: 10.1002/ajoc.201800426). [ABSTRACT FROM AUTHOR]