Haplotype analysis of distantly related populations implicates corneodesmosin in psoriasis susceptibility.

Authors :: Capon, F.
Toal, I.K.
Evans, J.C.
Allen, M.H.
Patel, S.
Tillman, D.
Burden, D.
Barker, J.N.W.N.
Trembath, R.C.
Source :: Journal of Medical Genetics; Jun2003, Vol. 40 Issue 6, p447-452, 6p, 1 Diagram, 4 Charts
Publication Year :: 2003
Abstract: Investigates the validity of the hypothesis of corneodesmosin (CDSN) involvement in psoriasis. Confirmation that the rare haplotype cluster D is a risk haplotype originating from the Gujurat region of northern India; Definition of CDSN genetic variation by an association study of intragenic single nucleotide polymorphism (SNP) haplotypes; Identification of 16 SNP chromosomes conferring significant disease risk both in the UK and the Gujuriti data sets.

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