Association of SNPs and haplotypes in GABAA receptor ß2 gene with schizophrenia.

Authors :: Lo, W.-S.
Lau, C.-F.
Xuan, Z.
Chan, C.-F.
Feng, G.-Y.
He, L.
Cao, Z.-C.
Liu, H.
Luan, Q.-M.
Xue, H.
Source :: Molecular Psychiatry; Jun2004, Vol. 9 Issue 6, p603-608, 6p
Publication Year :: 2004
Abstract: Disturbances in GABAergic system have been observed in schizophrenics.<superscript>1,2,3</superscript> In the present study, population association analysis was performed on 19 SNPs in the a<subscript>1</subscript>, ß<subscript>2</subscript>, ?<subscript>2</subscript>, ? and p subunit genes of GABA<subscript>A</subscript> receptor. Five SNPs in GABRB2, namely B2I7G1584T, rs1816071, rs194072, rs252944 and rs187269, were found to be significantly associated, and their haplotypes in linkage disequilibrium, with schizophrenia. This represents the first report on any disease association of SNPs in the human GABA<subscript>A</subscript> receptor genes, and focuses attention on the GABAergic hypothesis of schizophrenia etiology.<superscript>3,4</superscript>Molecular Psychiatry (2004) 9, 603-608. doi:10.1038/sj.mp.4001461 Published online 16 December 2003 [ABSTRACT FROM AUTHOR]

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