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Estimation of lean body mass by creatinine kinetics increases the prevalence of muscle wasting in peritoneal dialysis patients compared to bioimpedance.
- Source :
- European Journal of Clinical Nutrition; Oct2018, Vol. 72 Issue 10, p1455-1457, 3p, 1 Chart, 1 Graph
- Publication Year :
- 2018
-
Abstract
- Dialysis patients are at increased risk for muscle wasting, and time efficient screening tests are required for to allow for early detection. Creatinine kinetics have been advocated to estimate lean body mass (LBM) in peritoneal dialysis (PD) patients, and can be readily calculated in clinical practice from peritoneal dialysate effluent and urine collections. Bioimpedance is increasingly available, and we compared methods in 434 PD patients (55% men, 33.3% diabetics), mean age 55.2 ± 16.2 years. LBM was lower by creatinine kinetics (47.8 ± 16.6 kg men, 37.8 ± 11.2 kg women) vs. bioimpedance (53.2 ± 11.5 kg men, 39.2 ± 7.2 kg women), p < 0.01. The prevalence of muscle wasting was much greater using creatinine kinetics (72.4% men, 52.4% women) vs. bioimpedance (55.2% men, 37.3%), p < 0.05. Estimates of LBM were much lower using creatinine kinetics compared to bioimpedance. Studies reporting the prevalence of muscle loss in PD patients will differ depending upon the method used to estimate muscle mass. [ABSTRACT FROM AUTHOR]
- Subjects :
- BODY composition
BODY fluids
COMPARATIVE studies
CREATININE
DRUGS
DYNAMICS
HEMODIALYSIS
BIOELECTRIC impedance
RESEARCH methodology
MEDICAL cooperation
MUSCLES
PERITONEAL dialysis
RESEARCH
SEX distribution
EVALUATION research
DISEASE prevalence
WASTING syndrome
NUTRITIONAL status
PHOTON absorptiometry
Subjects
Details
- Language :
- English
- ISSN :
- 09543007
- Volume :
- 72
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- European Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 132271883
- Full Text :
- https://doi.org/10.1038/s41430-017-0072-z