Cerebral Oximetry for Detecting High-mortality Risk Patients with Cryptococcal Meningitis.

Background Cryptococcus is the commonest cause of adult meningitis in Africa, with 50%–70% experiencing increased intracranial pressure. Cerebral oximetry is a noninvasive near-infrared spectroscopy technology to monitor percent regional cerebral tissue oxygenation (rSO₂). We assessed if cerebral oximetry predicts meningitis mortality. Methods We performed cerebral oximetry within 14 days of cryptococcal meningitis diagnosis on 121 Ugandans from April 2016 to September 2017. We evaluated baseline rSO₂ association with mortality by multivariable logistic regression and correlation with other clinical factors. We compared groups formed by initial rSO₂ <30% vs ≥30% for longitudinal change with mixed effects models. We measured change in %rSO₂ before and after lumbar puncture (LP). Results The median initial rSO₂ (interquartile range) was 36% (29%–42%), and it was <30% in 29% (35/121). For 30-day mortality, the unadjusted odds ratio (per 5% increase in rSO₂) was 0.73 (95% confidence interval [CI], 0.58 to 0.91; P =.005). Those with initial rSO₂ <30% had 3.4 (95% CI, 1.5 to 8.0) higher odds of 30-day mortality than those with initial rSO₂ ≥30%. Hemoglobin correlated with initial rSO₂ (rho =.54; P <.001), but rSO₂ did not correlate with pulse oximetry, intracranial pressure, cerebral perfusion pressure, or quantitative cerebrospinal fluid culture, and rSO₂ was unchanged pre/post–lumbar punctures. The longitudinal rSO₂ measurements change was 15% (95% CI, 12% to 18%) lower in the group with initial rSO₂ <30%. Conclusions Individuals with cryptococcal meningitis and low cerebral oximetry (rSO₂ < 30%) have high mortality. Cerebral oximetry may be useful as a prognostic marker of mortality. Targeted interventions to improve rSO₂ should be tested in trials to try to decrease mortality in meningitis. [ABSTRACT FROM AUTHOR]