Development of a New Dynamic Headspace Liquid-Phase Microextraction Method.

A new technique, namely dynamic headspace liquid-phase microextraction, has been developed for the extraction of 1,4-dioxane in cosmetic and hygiene samples followed by gas chromatography-flame ionization detection. In this method, the sample is mixed with acetone as a diluent solvent. Then, a few microliters of n-octanol are added into a home-made extraction vessel placed in the headspace of the sample. By heating, the target analyte is transferred to the headspace of the sample and then extracted into n-octanol. Under the optimized conditions, the method showed a good linearity in the range of 3.24-1000 μg kg with a coefficient of determination 0.998. Figures of merit such as enrichment factor of 375, extraction recovery of 94 %, limits of detection and quantification 0.97 and 3.24 μg kg, respectively, and relative standard deviation 4.7 % ( n = 6, C = 30 μg kg) of the proposed method were satisfactory for determination of the target analyte. Finally, the method was successfully applied in determination of 1,4-dioxane in various cosmetic and hygiene samples including shampoo, toothpaste, lotion, washing liquid, and dishwashing liquid. [ABSTRACT FROM AUTHOR]