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An Update of Efficacy and Safety of Cetuximab in Metastatic Colorectal Cancer: A Narrative Review.

Authors :
Fornasier, Giulia
Francescon, Sara
Baldo, Paolo
Source :
Advances in Therapy; Oct2018, Vol. 35 Issue 10, p1497-1509, 13p
Publication Year :
2018

Abstract

Colorectal cancer is the second most common cancer, representing 13% of all diagnosed cancers. Cetuximab is a recombinant chimeric monoclonal IgG1 antibody and epidermal growth factor receptor (EGFR) inhibitor. Cetuximab is approved for the first-line treatment in combination with chemotherapy or as a single agent in patients who have failed or are intolerant to chemotherapy in patients with EGFR-expressing, RAS wild-type metastatic colorectal cancer. Cetuximab efficacy emerged from studies that were conducted to approve the drug. Cetuximab is well tolerated; its toxicities are caused by its mechanism of action and the most common adverse reaction is skin toxicity. The main purpose of this manuscript is to present an update on the evidence-based summary of efficacy and safety and on the cost-effectiveness of cetuximab. Furthermore, it suggests a management of adverse drug reactions to improve the tolerability of the drug. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0741238X
Volume :
35
Issue :
10
Database :
Complementary Index
Journal :
Advances in Therapy
Publication Type :
Academic Journal
Accession number :
132001487
Full Text :
https://doi.org/10.1007/s12325-018-0791-0