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Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men.
- Source :
- European Journal of Nutrition; Oct2018, Vol. 57 Issue 7, p2595-2606, 12p, 4 Charts
- Publication Year :
- 2018
-
Abstract
- Purpose: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case-control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and lifestyle factors.Methods: The study population consisted of 1010 cases occurring during a mean follow-up of 14.6 years, and 1817 controls matched on age and study entry date. We used national registers (95%) and hospital records (5%) to ascertain cases. Diet was estimated by a modified diet history method. Plasma ENL concentrations were determined by a time-resolved fluoroimmunoassay. Odds ratios were calculated by unconditional logistic regression.Results: There were no significant associations between plasma ENL and incidence of all prostate cancer (odds ratio 0.99 [95% confidence interval 0.77-1.280] for the highest ENL quintile versus lowest, p for trend 0.66). However, in certain subgroups of men, including men with abdominal obesity (p for interaction = 0.012), we observed associations between high ENL levels and lower odds of high-risk prostate cancer. Plasma ENL was positively associated with consumption of high-fibre bread, fruit, tea, and coffee; with age, and with height, while it was negatively associated with smoking and waist circumference; however, although significant, all associations were rather weak (r ≤ |0.14|).Conclusion: ENL concentration was not consistently associated with lower prostate cancer risk, although it was weakly associated with a healthy lifestyle. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROSTATE tumors
AGE distribution
BREAD
COFFEE
CONFIDENCE intervals
DIETARY fiber
FRUIT
HEALTH behavior
INGESTION
LIGNANS
NUTRITIONAL assessment
OBESITY
SMOKING
STATURE
TEA
LOGISTIC regression analysis
LIFESTYLES
CASE-control method
WAIST circumference
FLUOROIMMUNOASSAY
ODDS ratio
MIDDLE age
TUMOR risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 57
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 131975660
- Full Text :
- https://doi.org/10.1007/s00394-017-1530-z