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Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application.
- Source :
- Dalton Transactions: An International Journal of Inorganic Chemistry; 10/7/2018, Vol. 47 Issue 37, p12838-12842, 5p
- Publication Year :
- 2018
-
Abstract
- The two series of ruthenium–indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental–theoretical investigation suggests an unconventional 5-endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines. [ABSTRACT FROM AUTHOR]
- Subjects :
- RUTHENIUM
HETEROCYCLIC compounds
METAL complexes
Subjects
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 47
- Issue :
- 37
- Database :
- Complementary Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 131971669
- Full Text :
- https://doi.org/10.1039/c8dt02408a