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Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study.
- Source :
- Maternal & Child Nutrition; Oct2018, Vol. 14 Issue 4, p1-1, 7p
- Publication Year :
- 2018
-
Abstract
- Abstract: Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk‐based multiple micronutrient‐fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder. The effect of serum AFB<subscript>1</subscript>‐lysine adduct level on incremental growth was tested using a longitudinal mixed model, controlling for key individual, maternal, and household‐level covariates. AFB<subscript>1</subscript>‐lysine adduct was detectable in all but 2 of the 347 children in the study (median exposure: 0.82 pg/mg albumin). AF exposure was associated (p < .05) with greater linear growth: an increase equivalent to the sample interquartile range (~0.5 pg AFB<subscript>1</subscript>‐lysine/mg albumin) was associated (p < .05) with an increase in the child's height‐for‐age deficit of 1.5 to 2.0 mm in the 4 months from baseline (average age 8 months) to follow‐up (average age 12 months); the magnitude of the difference in the 10‐month follow‐up was smaller and not statistically significant. This study documents that low‐dose AF exposure was associated with greater child linear growth. Given its toxicity and carcinogenicity, our results do not change the urgent need to drastically reduce human AF exposure. Our findings show that the association between AF exposure and linear growth is more complex than previously thought. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENRICHED foods
AFLATOXINS
ANTHROPOMETRY
CHI-squared test
CLINICAL trials
COMPARATIVE studies
CORN
STATISTICAL correlation
CLINICAL pathology
DIETARY supplements
FOOD
GROWTH disorders
INGESTION
LONGITUDINAL method
RESEARCH methodology
MILK
NUTRITIONAL requirements
PROBABILITY theory
SURVEYS
T-test (Statistics)
MICRONUTRIENTS
ENVIRONMENTAL exposure
SECONDARY analysis
SOCIOECONOMIC factors
DATA analysis software
NUTRITIONAL value
Subjects
Details
- Language :
- English
- ISSN :
- 17408695
- Volume :
- 14
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Maternal & Child Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 131948801
- Full Text :
- https://doi.org/10.1111/mcn.12619