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Ventilation inhomogeneity in infants with recurrent wheezing.
- Source :
- Thorax; Oct2018, Vol. 73 Issue 10, p936-941, 6p, 3 Charts, 2 Graphs
- Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>The care of infants with recurrent wheezing relies largely on clinical assessment. The lung clearance index (LCI), a measure of ventilation inhomogeneity, is a sensitive marker of early airway disease in children with cystic fibrosis, but its utility has not been explored in infants with recurrent wheezing.<bold>Objective: </bold>To assess ventilation inhomogeneity using LCI among infants with a history of recurrent wheezing compared with healthy controls.<bold>Methods: </bold>This is a case-control study, including 37 infants with recurrent wheezing recruited from outpatient clinics, and 113 healthy infants from a longitudinal birth cohort, the Canadian Healthy Infant Longitudinal Development study. All infants, at a time of clinical stability, underwent functional assessment including multiple breath washout, forced expiratory flows and body plethysmography.<bold>Results: </bold>LCI z-score values among infants with recurrent wheeze were 0.84 units (95% CI 0.41 to 1.26) higher than healthy infants (mean (95% CI): 0.26 (-0.11 to 0.63) vs -0.58 (-0.79 to 0.36), p<0.001)). Nineteen percent of recurrently wheezing infants had LCI values that were above the upper limit of normal (>1.64 z-scores). Elevated exhaled nitric oxide, but not symptoms, was associated with abnormal LCI values in infants with recurrent wheeze (p=0.05).<bold>Conclusions: </bold>Ventilation inhomogeneity is present in clinically stable infants with recurrent wheezing. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00406376
- Volume :
- 73
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Thorax
- Publication Type :
- Academic Journal
- Accession number :
- 131876372
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2017-211351