System Dynamics Approach to Epidemic Compartment Model: Translating SEIR Model for MERS Transmission in South Korea.

Compartment models, a type of mathematical model, have been widely applied to characterize the changes in a dynamic system with sequential events or processes, such as the spread of an epidemic disease. A compartment model comprises compartments, and the relations between compartments are depicted as boxes and arrows. This principle is similar to that of the system dynamics (SD) approach to constructing a simulation model with stocks and flows. In addition, both models are structured using differential equations. With this mutual and translatable principle, this study, in terms of SD, translates a reference SEIR model, which was developed in a recent study to characterize the transmission of the Middle East respiratory syndrome (MERS) in South Korea. Compared to the replicated result of the reference SEIR model (Model 1), the translated SEIR model (Model 2) demonstrates the same simulation result (error=0). The results of this study provide insight into the application of SD relative to constructing an epidemic compartment model using schematization and differential equations. The translated SD artifact can be used as a reference model for other epidemic diseases. [ABSTRACT FROM AUTHOR]