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Cortical Reshaping and Functional Recovery Induced by Silk Fibroin Hydrogels-Encapsulated Stem Cells Implanted in Stroke Animals.
- Source :
- Frontiers in Cellular Neuroscience; 9/6/2018, pN.PAG-N.PAG, 16p
- Publication Year :
- 2018
-
Abstract
- The restitution of damaged circuitry and functional remodeling of peri-injured areas constitute two main mechanisms for sustaining recovery of the brain after stroke. In this study, a silk fibroin-based biomaterial efficiently supports the survival of intracerebrally implanted mesenchymal stem cells (mSCs) and increases functional outcomes over time in a model of cortical stroke that affects the forepaw sensory and motor representations. We show that the functional mechanisms underlying recovery are related to a substantial preservation of cortical tissue in the first days after mSCs-polymer implantation, followed by delayed cortical plasticity that involved a progressive functional disconnection between the forepaw sensory (FLs<subscript>1</subscript>) and caudal motor (cFLm<subscript>1</subscript>) representations and an emergent sensory activity in peri-lesional areas belonging to cFLm<subscript>1</subscript>. Our results provide evidence that mSCs integrated into silk fibroin hydrogels attenuate the cerebral damage after brain infarction inducing a delayed cortical plasticity in the peri-lesional tissue, this later a functional change described during spontaneous or training rehabilitation-induced recovery. This study shows that brain remapping and sustained recovery were experimentally favored using a stem cell-biomaterial-based approach. [ABSTRACT FROM AUTHOR]
- Subjects :
- SILK fibroin
MESENCHYMAL stem cells
STROKE
POLYMERS
BIOMATERIALS
Subjects
Details
- Language :
- English
- ISSN :
- 16625102
- Database :
- Complementary Index
- Journal :
- Frontiers in Cellular Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 131630402
- Full Text :
- https://doi.org/10.3389/fncel.2018.00296