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Shwachman–Diamond syndrome: Nationwide survey and systematic review in Japan.
- Source :
- Pediatrics International; Aug2018, Vol. 60 Issue 8, p719-726, 8p
- Publication Year :
- 2018
-
Abstract
- Abstract: Background: Shwachman–Diamond syndrome (SDS) is a rare multisystem disorder associated with exocrine pancreatic insufficiency. The present study reports the results of a nationwide survey and a systematic review on SDS to develop consensus guidelines for intractable diarrhea including SDS. Methods: Questionnaires were sent to 616 departments of pediatrics or of pediatric surgery in Japan in a nationwide survey. A second questionnaire was sent to doctors who had treated SDS patients and included questions on clinical information. Additionally, a systematic review was performed using digital literature databases to assess the influence of medical (i.e. non‐surgical) treatment on SDS prognosis. Results: Answers were received from 529 institutions (85.9%), which included information on 24 patients with SDS (median age, 10.4 years; male, n = 15) treated from January 2005 to December 2014. Although 75% of patients received pancreatic enzyme replacement therapy, there was no significant association between treatment and prognosis. Systematic review identified one clinical practice guideline, two case series, eight case reports and 26 reviews. Patient information from those studies was insufficient for meta‐analysis. Conclusions: The rarity of SDS makes it difficult to establish evidence‐based treatment for SDS. According to the limited information from patients and published reports, medical treatment for malabsorption due to SDS should be performed to improve fat absorption and stool condition, but it is not clear whether this treatment improves the prognosis of malabsorption. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of enzymes
PEDIATRIC surgery
CLINICAL medicine
CONSENSUS (Social sciences)
DIARRHEA
FAT
FECES
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL protocols
MALABSORPTION syndromes
PANCREAS
PEDIATRICS
PHYSICIANS
POLICY sciences
QUESTIONNAIRES
SURVEYS
SYSTEMATIC reviews
EVIDENCE-based medicine
SHWACHMAN-Diamond Syndrome
DISEASE complications
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 13288067
- Volume :
- 60
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Pediatrics International
- Publication Type :
- Academic Journal
- Accession number :
- 131499501
- Full Text :
- https://doi.org/10.1111/ped.13601