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A European myocardial 123I-mIBG cross-calibration phantom study.
- Source :
- Journal of Nuclear Cardiology; Aug2018, Vol. 25 Issue 4, p1191-1197, 7p
- Publication Year :
- 2018
-
Abstract
- <bold>Aim: </bold>Planar myocardial 123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy is a highly reproducible technique. However, differences in collimator use are one of the most important factors that cause variation among institutions and studies in heart-to-mediastinum (H/M) ratio. Therefore, standardization among various gamma camera-collimator combinations is needed. Previously, a phantom has been developed to cross-calibrate different acquisition conditions in Japan. For further cross-calibration of European myocardial 123I-mIBG imaging, the aim of this study was to collect 123I-mIBG data for H/M ratios from common European gamma camera vendors.<bold>Methods: </bold>210 experiments were performed in 27 European institutions. Based on these experiments, conversion coefficients for each gamma camera-collimator combination were calculated. An averaged conversion coefficient of 0.88 was used to calculate a standardized H/M ratio.<bold>Results: </bold>On average, LE-collimator-derived H/M ratios were significantly lower compared to ME-collimator-derived H/M ratios. The mean conversion coefficients ranged from 0.553 to 0.605 for the LE-collimator group and from 0.824 to 0.895 for the ME-collimator group.<bold>Conclusion: </bold>Clinically established H/M ratios can be converted into standardized H/M ratios using cross-calibrated conversion coefficients. This standardization is important for identifying appropriate thresholds for adequate risk stratification. In addition, this cross-calibration enables comparison between different national and international data. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10713581
- Volume :
- 25
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Nuclear Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 131405796
- Full Text :
- https://doi.org/10.1007/s12350-017-0782-6