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Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals.
- Source :
- Angewandte Chemie International Edition; 8/27/2018, Vol. 57 Issue 35, p11413-11417, 5p
- Publication Year :
- 2018
-
Abstract
- Abstract: An alkoxyl radical guided strategy for site‐selective functionalization of unactivated methylene and methine C−H bonds enabled by an Fe<superscript>II</superscript>‐catalyzed redox process is described. The mild, expeditious, and modular protocol allows efficient remote aliphatic fluorination, chlorination, amination, and alkynylation of structurally and electronically varied primary, secondary, and tertiary hydroperoxides with excellent functional‐group tolerance. The application for one‐pot 1,4‐hydroxyl functionalization of non‐oxygenated alkane substrates initiated by aerobic C−H oxygenation is also demonstrated. [ABSTRACT FROM AUTHOR]
- Subjects :
- IRON catalysts
ALKOXYL radicals
CHLORINATION
HYDROPEROXIDES
AMINATION
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 57
- Issue :
- 35
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 131373535
- Full Text :
- https://doi.org/10.1002/anie.201806434