Safety of moderate-to-deep sedation performed by sedation practitioners: A national prospective observational study.

<bold>Background: </bold>In the Netherlands, a significant proportion of moderate-to-deep sedation is performed by sedation practitioners under the indirect supervision of an anaesthesiologist but there are limited safety data available.<bold>Objective: </bold>To estimate the rate of sedation-related adverse events and patient relevant outcomes (PRO).<bold>Design: </bold>This was a prospective national observational study. Data were collected with a modified adverse event reporting tool from the International Sedation Task Force of the World Society of Intravenous Anaesthesia.<bold>Setting: </bold>A total of 24 hospitals in the Netherlands where moderate-to-deep sedation was performed by sedation practitioners from the 1 February 2015 to 1 March 2016.<bold>Patients: </bold>Consecutive adults undergoing moderate-to-deep sedation for gastrointestinal, pulmonary and cardiac procedures.<bold>Intervention: </bold>Observation: Analysis included descriptive statistics and a multivariate logistic regression model for an association between adverse events and PRO.<bold>Main Outcome Measures: </bold>The primary outcome was the rate of unfavourable PRO (admission to ICU, permanent neurological deficit, pulmonary aspiration or death). Secondary outcome was the rate of moderate-to-good PRO (unplanned hospital admission or escalation of care). Composite outcome was the sum of all primary and secondary outcomes.<bold>Results: </bold>A total of 11 869 patients with a median age of 64 years [interquartile range 51 to 72] were included. ASA physical score distribution was: first, 19.1%; second, 57.6%; third, 21.6%; fourth, 1.2%. Minimal adverse events occurred in 1517 (12.8%), minor adverse events in 113 (1.0%) and major adverse events in 80 instances (0.7%).<bold>Primary Outcome: </bold>Five (0.04%) unfavourable PRO were observed; four patients needing admission to the intensive care unit; and one died. Secondary outcome: 12 (0.1%) moderate-to-good PRO were observed. Moderate and major adverse events were associated with the composite outcome [3.7 (95% confidence interval 1.1 to 11.9) and 40.6 (95% confidence interval 11.0 to 150.4)], but not minimal or minor adverse events.<bold>Conclusion: </bold>Moderate-to-deep sedation performed by trained sedation practitioners has a very low rate of unfavourable outcome. [ABSTRACT FROM AUTHOR]