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Combined percutaneous radiofrequency ablation and ethanol injection versus hepatic resection for 2.1-5.0 cm solitary hepatocellular carcinoma: a retrospective comparative multicentre study.
- Source :
- European Radiology; Sep2018, Vol. 28 Issue 9, p3651-3660, 10p, 1 Diagram, 4 Charts, 2 Graphs
- Publication Year :
- 2018
-
Abstract
- <bold>Objectives: </bold>To compare combined percutaneous radiofrequency ablation and ethanol injection (RFA-PEI) with hepatic resection (HR) in the treatment of resectable solitary hepatocellular carcinoma (HCC) with 2.1-5.0 cm diameter.<bold>Methods: </bold>From June 2009 to December 2015, 271 patients whom underwent RFA-PEI (n = 141) or HR (n = 130) in three centres were enrolled. The overall survival (OS) and recurrence-free survival (RFS) between groups were compared with Kaplan-Meier method and log-rank tests. Complications, hospital stay and cost were assessed.<bold>Results: </bold>The OS rates at 1, 3 and 5 years were 93.5%, 72.7%, 58.6% in RFA-PEI group and 82.3%, 57.5%, 51.8% in HR group (p = 0.021). The corresponding 1-, 3- and 5-year RFS rates were 65.8%, 41.3%, 34.3% in RFA-PEI group and 50.5%, 33.8%, 28.4% in HR group (p = 0.038). For patients with 2.1-3.0 cm tumours, the 1-, 3- and 5-year OS after RFA-PEI and HR were 98.0%, 82.3%, 74.2% and 89.4%, 65.1%, 61.9%, respectively (p = 0.024). The corresponding RFS were 79.6%, 54.7%, 45.1% in RFA-PEI group, and 57.6%, 43.9%, 31.7% in HR group, respectively (p = 0.020). RFA-PEI was superior to HR in major complication rates, length of hospital stay and cost (all p < 0.001).<bold>Conclusion: </bold>RFA-PEI had a survival benefit over HR in the treatment of solitary HCCs, especially for those with 2.1-3.0 cm in diameter.<bold>Key Points: </bold>• RFA-PEI provided superior survival to HR in solitary HCC with 2.1-5.0 cm in diameter. • RFA-PEI is superior to HR in complications, length of hospital stay and cost. • RFA-PEI might be an alternative treatment for solitary HCC within 5.0 cm in diameter. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIVER cancer
CATHETER ablation
RADIO frequency therapy
SURGICAL excision
RETROSPECTIVE studies
TUMOR treatment
CANCER relapse
COMBINED modality therapy
COMPARATIVE studies
ETHANOL
HEPATECTOMY
HEPATOCELLULAR carcinoma
LENGTH of stay in hospitals
INJECTIONS
LIVER tumors
RESEARCH methodology
MEDICAL cooperation
RESEARCH
RESEARCH funding
SURVIVAL analysis (Biometry)
EVALUATION research
TREATMENT effectiveness
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09387994
- Volume :
- 28
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- European Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 131115231
- Full Text :
- https://doi.org/10.1007/s00330-018-5371-9