Back to Search Start Over

Timing of myocardial shortening determines left ventricular regional myocardial work and regional remodelling in hearts with conduction delays.

Authors :
Cvijic, Marta
Duchenne, Jürgen
Ünlü, Serkan
Michalski, Blazej
Aarones, Marit
Winter, Stefan
Aakhus, Svend
Fehske, Wolfgang
Stankovic, Ivan
Voigt, Jens-Uwe
Source :
European Heart Journal - Cardiovascular Imaging; Aug2018, Vol. 19 Issue 8, p941-949, 9p
Publication Year :
2018

Abstract

Aims The interaction between asynchronous regional myocardial activation and left ventricular (LV) wall remodelling has not been well established. We investigated the relationship between time of onset of longitudinal shortening (T <subscript>onset</subscript>), regional myocardial work, and segmental LV wall thickness (SWT) in patients treated with cardiac resynchronization therapy (CRT). Methods and results We analysed 26 patients with sinus rhythm, non-ischaemic cardiomyopathy (63 ± 9 years, 69% male, QRS duration 174 ± 18 ms) and positive response to CRT (15% reduction in end-systolic volume). Longitudinal strain was obtained by 2D speckle-tracking echocardiography before and after [14.5 (7–29) months] CRT. T <subscript>onset</subscript> and SWT were measured in 18 segments per LV. Segmental myocardial work was calculated from non-invasive segmental stress–strain loop area. Before CRT, T <subscript>onset</subscript> was the shortest in septal and anteroseptal and the longest in lateral and posterior walls (P  < 0.001) and not different after CRT (P  = 0.733). Before CRT, septal and anteroseptal walls were significantly thinner than lateral and posterior. After CRT, reverse remodelling increased thickness in septal and anteroseptal and thinned lateral and posterior segments (P  < 0.001). Before CRT, non-uniformity in work distribution with reduced work in septal and anteroseptal and increased work in lateral and posterior walls (P  < 0.001) was observed. After CRT, distribution of myocardial work was uniform (P  = 0.215). Conclusion Dys-synchronous myocardial shortening is related to thinning of early and thickening of late activated segments in heart failure with conduction delay. Correction of dys-synchrony leads to regression of inhomogeneity towards more evenly distributed wall thickness. Regional differences in myocardial work load that are homogenized by successful CRT are considered as the underlying pathophysiological mechanism. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20472404
Volume :
19
Issue :
8
Database :
Complementary Index
Journal :
European Heart Journal - Cardiovascular Imaging
Publication Type :
Academic Journal
Accession number :
130914949
Full Text :
https://doi.org/10.1093/ehjci/jex325