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The Emerging Importance of Liver Sinusoidal Endothelial Cells in Regulating Injury during Machine Perfusion of Deceased Liver Donors.
- Source :
- Seminars in Liver Disease; 2018, Vol. 38 Issue 3, p252-259, 8p
- Publication Year :
- 2018
-
Abstract
- While majority of liver transplants worldwide continue to be performed using deceased donor organs, the demands for donor livers continues to exceed the current supply. In an attempt to maximize the number of potentially usable donor livers and expand the current donor pool, there is intense global research by various groups exploring the role of machine perfusion in the liver transplantation, particularly with respect to the machine perfusion of extended-criteria liver donors. In this review, the authors summarize the current field of machine perfusion strategies as applied to deceased donor liver transplantation and how therapeutic targeting of the liver sinusoidal endothelial cell may improve the quality of donor livers. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENDOTHELIAL cells
LIVER transplantation
ORGAN donors
ISCHEMIA
REPERFUSION injury
Subjects
Details
- Language :
- English
- ISSN :
- 02728087
- Volume :
- 38
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Seminars in Liver Disease
- Publication Type :
- Academic Journal
- Accession number :
- 130906990
- Full Text :
- https://doi.org/10.1055/s-0038-1661371