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Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro.
- Source :
- Journal of Oral Pathology & Medicine; Jan1998, Vol. 27 Issue 1, p11-17, 7p
- Publication Year :
- 1998
-
Abstract
- The bcl-2 proto-oncogene is a known inhibitor of apoptosis; in normal human stratified squamous epithelium, its expression is restricted to the basal cell layer. To investigate the functional role of bcl-2 protein in the process of differentiation of oral keratinocytes, bcl-2 expression vector was transfected into SCC-25 cells, which normally undergo squamous cell differentiation in vitro while expressing specific differentiation markers, e.g., keratin 10/11 and involucrin. In bcl-2 transfected SCC-25 cells, the expression of these differentiation markers was markedly suppressed. The bcl-2 proto-oncogene may play a critical role in opposing the commitment to terminal differentiation and apoptosis of oral keratinocytes. [ABSTRACT FROM AUTHOR]
- Subjects :
- APOPTOSIS
CELL death
CELLS
EPITHELIUM
TISSUES
KERATINOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 09042512
- Volume :
- 27
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Oral Pathology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 13078451
- Full Text :
- https://doi.org/10.1111/j.1600-0714.1998.tb02084.x