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Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma.
Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma.
- Source :
- Clinical & Experimental Allergy; May2004, Vol. 34 Issue 5, p757-760, 4p
- Publication Year :
- 2004
-
Abstract
- Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma. In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV<subscript>1</subscript> decline. The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV<subscript>1</subscript> ( P<0.05). These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09547894
- Volume :
- 34
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 13077919
- Full Text :
- https://doi.org/10.1111/j.1365-2222.2004.1938.x