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Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma.

Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma.

Authors :
Jongepier, H.
Boezen, H. M.
Dijkstra, A.
Howard, T. D.
Vonk, J. M.
Koppelman, G. H.
Zheng, S. L.
Meyers, D. A.
Bleecker, E. R.
Postma, D. S.
Source :
Clinical & Experimental Allergy; May2004, Vol. 34 Issue 5, p757-760, 4p
Publication Year :
2004

Abstract

Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma. In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV<subscript>1</subscript> decline. The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV<subscript>1</subscript> ( P<0.05). These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09547894
Volume :
34
Issue :
5
Database :
Complementary Index
Journal :
Clinical & Experimental Allergy
Publication Type :
Academic Journal
Accession number :
13077919
Full Text :
https://doi.org/10.1111/j.1365-2222.2004.1938.x