Late stage modifications of P-containing ligands using transition-metal-catalysed C–H bond functionalisation.

Phosphorus containing molecules have seen widespread applications in the development of innovative metal-ligand catalysts and materials. In recent years, the implementation of late-stage modifications of phosphorus derivatives via ortho-regioselective C–H bond functionalisation has led to faster and better ways for the synthesis of complex ligands by creating new reactions with low impact on the environment. This Feature article highlights transition-metal catalysed regioselective C–H bond functionalisation of phosphorus-containing molecules, in which the phosphorus containing unit plays the role of a directing group for C–H bond activation and the synthesis of new functional phosphorus derivatives. [ABSTRACT FROM AUTHOR]