Anti-titin antibodies are not associated with a specific thymoma histology.

The article studies the association of Anti-titin antibodies with thymoma histology. After the first description of antibodies to titin patients with thymoma associated myasthenia gravis in 1990, this finding was independently confirmed and the main immunogenic region of titin identified. The presence of anti-titin point towards an underlying thymoma. If consistent with radiology, thymectomy is performed also to exclude the presence of an infiltrating thymic carcinoma. As the research data now show, titin antibodies are not correlated with thymoma histology and therefore do not add to the presurgical information on the tumour.