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Catalytic Enantioselective Cloke–Wilson Rearrangement.
- Source :
- Angewandte Chemie International Edition; 7/2/2018, Vol. 57 Issue 27, p8225-8229, 5p
- Publication Year :
- 2018
-
Abstract
- Abstract: Racemic cyclopropyl ketones undergo enantioselective rearrangement to deliver the corresponding dihydrofurans in the presence of a chiral phosphoric acid as the catalyst. The reaction involves activation of the donor‐acceptor cyclopropane substrate by the chiral Brønsted acid catalyst to promote the ring‐opening event, thus generating a carbocationic intermediate that subsequently undergoes cyclization. Computational studies and control experiments support this mechanistic pathway. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 57
- Issue :
- 27
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 130361572
- Full Text :
- https://doi.org/10.1002/anie.201804614