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The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough.
- Source :
- Nature Biotechnology; May2004, Vol. 22 Issue 5, p554-559, 6p
- Publication Year :
- 2004
-
Abstract
- <em>Desulfovibrio vulgaris</em> Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the `hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-Ill protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration. [ABSTRACT FROM AUTHOR]
- Subjects :
- DESULFOVIBRIO
GENOMES
CYTOCHROMES
BIOREMEDIATION
METABOLISM
ENZYMES
Subjects
Details
- Language :
- English
- ISSN :
- 10870156
- Volume :
- 22
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Nature Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 13008908
- Full Text :
- https://doi.org/10.1038/nbt959