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Delivery of vinblastine-containing niosomes results in potent in vitro/in vivo cytotoxicity on tumor cells.

Delivery of vinblastine-containing niosomes results in potent in vitro/in vivo cytotoxicity on tumor cells.

Authors :
Amiri, Boshra
Ahmadvand, Hasan
Farhadi, Ali
Najmafshar, Aazam
Chiani, Mohsen
Norouzian, Dariush
Source :
Drug Development & Industrial Pharmacy; Aug2018, Vol. 44 Issue 8, p1371-1376, 6p
Publication Year :
2018

Abstract

Vinblastine (VB), as a chemotherapeutic agent, is widely used in treatment of different types of cancer. However, its clinical application is limited due to its low water solubility, side effects, and multidrug resist- ance. The aim of this study was to increase the therapeutic efficacy of VB using drug delivery systems. For this purpose, a PEGylated niosomal formulation of vinblastine (Pn-VB) was prepared by thin film hydration method and physicochemically characterized. Drug release pattern was performed by dialysis diffusion method. The cytotoxicity of Pn-VB was investigated against murine lung cancer TC-1 cells using MTT assay and its tumor inhibitory effect was evaluated in lung tumor-bearing C57BL/6 mice. Mean particle size, zeta potential, entrapment, and loading efficiency of niosomes were obtained to be about 234.3 ± 11.4 nm, -34.6 ± 4.2mV, 99.92 ± 1.6%, and 2.673 ± 0.30%, respectively. While, the mean particle size and zeta potential for non-PEGylated niosomes were obtained about 212.4 nm and -31.4mV, respectively. The in vitro release pattern of drug from niosomes showed a sustained release behavior. Pn-VB indicated a significant increase in toxicity against TC-l cells as compared to free VB. In animal model, Pn-VB exhibited stronger tumor inhibitory effect and longer life time in comparison to free VB. In conclusion, Pn-VB showed appropriate stability, high-entrapment efficacy, lower releasing rate, and stronger cytotoxic activity against lung cancer TC-1 cells as compared to free drug. Thus, the Pn-VB could be a promising formulation for delivery of vinblastine to tumor cells with enhanced drug bioavailability and therapeutic efficacy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03639045
Volume :
44
Issue :
8
Database :
Complementary Index
Journal :
Drug Development & Industrial Pharmacy
Publication Type :
Academic Journal
Accession number :
130068546
Full Text :
https://doi.org/10.1080/03639045.2018.1451880