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Divergent Coupling of Anilines and Enones by Integration of C@H Activation and Transfer Hydrogenation.
- Source :
- Angewandte Chemie International Edition; 5/28/2018, Vol. 57 Issue 22, p6681-6685, 5p
- Publication Year :
- 2018
-
Abstract
- Cp*Rh<superscript>III</superscript>/Ir<superscript>III</superscript> complexes are known to play important roles in both C@H activation and transfer hydrogenation (TH). However, these two areas evolved separately. They have been integrated in redox- and chemodivergent coupling reactions of N-pyridylanilines with enones. The iridiumcatalyzed coupling with enones leads to the efficient synthesis of tetrahydroquinolines through TH from <superscript>i</superscript>PrOH. Counterintuitively, iPrOH does not serve as the sole hydride source, and the major reaction pathway involves disproportionation of a dihydroquinoline intermediate, followed by the convergent and iterative reduction of quinolinium species. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 57
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 129880818
- Full Text :
- https://doi.org/10.1002/anie.201803347