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The Impact of Obesity on Breast Cancer.
- Source :
- Current Oncology Reports; Jun2018, Vol. 20 Issue 6, p1-1, 1p
- Publication Year :
- 2018
-
Abstract
- The rates of obesity are increasing worldwide and this condition is now recognized as a leading preventable cause of cancer. Several diseases are directly related to obesity, including diabetes, hypertension, atherosclerosis, stroke, musculoskeletal disorders, and a diverse range of malignances—such as breast cancer. Obesity is associated with an increased risk of postmenopausal estrogen receptor-positive breast cancer and worse cancer-related outcomes for all breast tumor subtypes. Several mechanisms have been proposed to contribute to the obesity-cancer link, including high levels of circulating and local estrogens, altered amounts of adipokines (leptin and adiponectin), disrupted insulin/IGF signaling, modifications within the microbiome, and local and systemic effects of inflammation. Here we will review recent advances in our understanding of the complex signaling pathways underlying the obesity-cancer link. An improved understanding of these processes is anticipated to propel novel and effective intervention strategies to reduce the global obesity-cancer burden. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15233790
- Volume :
- 20
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Current Oncology Reports
- Publication Type :
- Academic Journal
- Accession number :
- 129812023
- Full Text :
- https://doi.org/10.1007/s11912-018-0688-8