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Simultaneous early-onset severe autoimmune hemolytic anemia and albuminuria during alemtuzumab treatment for multiple sclerosis.
- Source :
- Multiple Sclerosis Journal; May2018, Vol. 24 Issue 6, p813-815, 3p
- Publication Year :
- 2018
-
Abstract
- Background: Alemtuzumab, approved for multiple sclerosis (MS), can cause secondary autoimmune adverse events including thyroid disorders, immune thrombocytopenia (ITP), and glomerular nephropathies. Non-ITP autoimmune cytopenias are rarely reported. Objective: To report a case of autoimmune hemolytic anemia (AIHA) and nephropathy in a MS patient treated with alemtuzumab. Case report: A 34-year-old man with MS developed albuminuria and AIHA after the first and only alemtuzumab treatment, with positive Coombs’ direct and indirect tests and IgG autoantibodies. Both AIHA and nephropathy resolved 1 month after treatment with steroids and intravenous immunoglobulins. Conclusion: Our report adds to literature on AIHA and nephropathy after alemtuzumab treatment and suggests to add Coombs’ tests to the screening panel required for alemtuzumab treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALEMTUZUMAB
MULTIPLE sclerosis
AUTOIMMUNE diseases
THROMBOCYTOPENIA
KIDNEY diseases
Subjects
Details
- Language :
- English
- ISSN :
- 13524585
- Volume :
- 24
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Multiple Sclerosis Journal
- Publication Type :
- Academic Journal
- Accession number :
- 129774661
- Full Text :
- https://doi.org/10.1177/1352458517743093