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Joint effects of fatty acid desaturase 1 polymorphisms and dietary polyunsaturated fatty acid intake on circulating fatty acid proportions.
- Source :
- American Journal of Clinical Nutrition; May2018, Vol. 107 Issue 5, p826-833, 8p
- Publication Year :
- 2018
-
Abstract
- Background: Polyunsaturated fatty acids (PUFAs) are associated with a lower risk of multiple diseases. Fatty acid desaturase 1 gene (FADSl) polymorphisms and dietary PUFA intake are both established determinants of circulating PUFA proportions. Objective: We explored the joint effects of FADSl polymorphisms and dietary PUFA intake on circulating PUFA proportions. Design: We studied 2288 participants from a nested case-control study of coronary artery disease among participants who provided blood samples in the Nurses' Health Study and the Health Professionals Follow-Up Study. Dietary PUFA intake was obtained from semiquantitative food-frequency questionnaires. FADSl rs174546 was genotyped by using the Affymetrix 6.0 platform, and circulating PUFA proportions were measured with gas-liquid chromatography. Linear regression models were used to examine the associations between rs174546 and circulating proportions of each fatty acid. Gene-diet interactions were tested by including a cross-product term of dietary intake of each PUFA by rs174546 genotype in the linear regression models. Results: After adjustment for sex and ancestry, each copy of the C allele of rs174546 was associated with higher circulating pro-portions of arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) and lower proportions of linoleic acid and a-linolenic acid. The magnitude of positive association between higher consumption of dietary EPA or DHA and circulating pro-portions of EPA increased with each copy of the rs174546_T allele (P-interaction = 0.01 and 0.007, respectively). Each 1-SD increment in EPA intake was associated with an average 3.7% increase in circulating EPA proportions among participants with the rs174546_CC genotype and an average 7.8% increase among participants with the TT genotype. Conclusions: Carriers of the T allele at FADSl rs174546 may need higher doses of dietary EPA and DHA to achieve the same circulating proportions of EPA as carriers of the C allele. The implications of these findings on disease risk and dietary guidelines require further study. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALLELES
CONFIDENCE intervals
FAT content of food
GENETIC polymorphisms
INGESTION
MEDICAL personnel
NUTRITIONAL assessment
PROBABILITY theory
QUESTIONNAIRES
REGRESSION analysis
STATISTICAL hypothesis testing
STATISTICS
T-test (Statistics)
UNSATURATED fatty acids
DOCOSAHEXAENOIC acid
EICOSAPENTAENOIC acid
DATA analysis
CASE-control method
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
GENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 107
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 129729337
- Full Text :
- https://doi.org/10.1093/ajcn/nqy025