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Hyperbaric oxygen suppresses growth of Klebsiella pneumoniae and enhances effect of tigecycline in vitro.
- Source :
- Undersea & Hyperbaric Medicine; Dec2017, Vol. 44 Issue 6, p543-549, 7p
- Publication Year :
- 2017
-
Abstract
- Objectives: (1) To examine whether hyperbaric oxygen (HBO<subscript>2</subscript>) will inhibit growth of multidrug-resistant Klebsiella pneumoniae (MDR-K. pneumoniae) and extensively drug-resistant Klebsiella pneumoniae (XDR-K. pneumoniae); (2) To determine whether the effect of tigecycline on XDR-K. pneumoniae will be enhanced by HBO<subscript>2</subscript>. Methods: The effects of 1.5 hours of treatment with normoxia (21% O<subscript>2</subscript>, 1 atmosphere absolute/ATA) or HBO<subscript>2</subscript> (100% O<subscript>2</subscript>, 2 ATA) on bacterial counts of eight isolates of MDR-K. pneumoniae and eight isolates of XDR-K. pneumoniae were studied. The effects of five hours of treatment with normoxia (21% O<subscript>2</subscript>, 1 ATA), tigecycline (21% O<subscript>2</subscript>, 1 ATA), HBO<subscript>2</subscript> (100% O<subscript>2</subscript>, 3 ATA) or HBO<subscript>2</subscript> + tigecycline (100% O<subscript>2</subscript>, 3 ATA) on proliferation of 10 isolates of XDR-K. pneumoniae were investigated. Results: HBO<subscript>2</subscript> at 100% O<subscript>2</subscript>, 2 ATA, 1.5 hours suppressed growth of MDR-K. pneumoniae but had no effect on XDR-K. pneumoniae. HBO<subscript>2</subscript> at 100% O<subscript>2</subscript>, 3 ATA, five hours enhanced the effects of tigecycline on XDR-K. pneumoniae. Conclusion: HBO<subscript>2</subscript> in combination with or without tigecycline can be used to eliminate K. pneumoniae in vitro, and such treatment may be beneficial for patients with infections caused by K. pneumoniae. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10662936
- Volume :
- 44
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Undersea & Hyperbaric Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 129645351
- Full Text :
- https://doi.org/10.22462/11.12.2017.5