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The G·U wobble base pair.
- Source :
- EMBO Reports; Jul2000, Vol. 1 Issue 1, p18-23, 6p
- Publication Year :
- 2000
-
Abstract
- The G˙U wobble base pair is a fundamental unit of RNA secondary structure that is present in nearly every class of RNA from organisms of all three phylogenetic domains. It has comparable thermodynamic stability to Watson-Crick base pairs and is nearly isomorphic to them. Therefore, it often substitutes for G˙C or A˙U base pairs. The G˙U wobble base pair also has unique chemical, structural, dynamic and ligand- binding properties, which can only be partially mimicked by Watson-Crick base pairs or other mispairs. These features mark sites containing G˙U pairs for recognition by proteins and other RNAS and allow the wobble pair to play essential functional roles in a remarkably wide range of biological processes. [ABSTRACT FROM AUTHOR]
- Subjects :
- RNA
ORGANISMS
PHYLOGENY
LIGANDS (Biochemistry)
RIBOSE
NUCLEIC acids
Subjects
Details
- Language :
- English
- ISSN :
- 1469221X
- Volume :
- 1
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- EMBO Reports
- Publication Type :
- Academic Journal
- Accession number :
- 12956571
- Full Text :
- https://doi.org/10.1093/embo-reports/kvd001