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Frequency and Correlates of Subjective Memory Complaints in Parkinson's Disease with and without Mild Cognitive Impairment: Data from the Parkinson's Disease Cognitive Impairment Study.
- Source :
- Journal of Alzheimer's Disease; 2018, Vol. 63 Issue 3, p1015-1024, 10p
- Publication Year :
- 2018
-
Abstract
- Subjective memory complaints (SMC) may represent the preclinical phase of mild cognitive impairment (MCI) due to Alzheimer's disease. Dementia/MCI have been described with a high prevalence in Parkinson's disease (PD), but whether SMC may predict the development of cognitive impairment has been barely explored. To evaluate the frequency and clinical correlates of isolated SMC (PD-SMC) or within the construct of MCI in subjects with PD, 147 PD patients from the PArkinson's disease COgnitive impairment Study (PACOS) were consecutively recruited for the study. This is a multicenter study involving two Movement Disorder Centers in south Italy. All subjects underwent comprehensive neuropsychological evaluation and PD-MCI was diagnosed according to Litvan's criteria. The Memory Assessment Clinics Questionnaire was used to assess SMC. Logistic regression analysis, adjusted for demographics and significant covariates, was used to evaluate clinical differences between groups. Forty-two (28.6%) individuals presented with PD without SMC and/or MCI (PDw), 40 (27,2%) with PD-SMC, 48 (32,6%) PD-SMC-MCI, and 17 (11,6%) PD-MCI without SMC (PD-MCI). When compared to PDw, PD-SMC was significantly associated with anxiety (OR = 3.93, 95% CI = 1.18-13.03), while PD-SMC-MCI related to motor progression (OR = 5.29, 95% CI = 1.12-24.86), and instrumental disability (OR = 6.98, 95% CI = 2.08-23.38). About 60% of patients showed SMC, in isolation or within the MCI frame. The role of SMC in PD seems to have a different etiology depending on the presence/absence of MCI. In particular, PD-SMC would represent a subjective reaction to the disease, while PD-SMC-MCI would depict motor progression and disability. [ABSTRACT FROM AUTHOR]
- Subjects :
- MILD cognitive impairment
PARKINSON'S disease
ANXIETY
REGRESSION analysis
MOTOR ability
ATTENTION
COGNITION disorders
COMPARATIVE studies
NEUROPSYCHOLOGICAL tests
RESEARCH methodology
MEDICAL cooperation
MEMORY disorders
NONPARAMETRIC statistics
QUESTIONNAIRES
RESEARCH
VISUAL perception
EVALUATION research
CROSS-sectional method
RETROSPECTIVE studies
EXECUTIVE function
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 63
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 129526861
- Full Text :
- https://doi.org/10.3233/JAD-171172