Back to Search
Start Over
Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014.
- Source :
- Heart; Jun2018, Vol. 104 Issue 11, p945-948, 4p
- Publication Year :
- 2018
-
Abstract
- <bold>Objective: </bold>To examine the risk for cyanotic congenital heart diseases (CCHDs) among live births in the USA, resulting from various forms of infertility treatments.<bold>Methods: </bold>This study is a cross-sectional analysis of live births in the USA from 2011 to 2014. Infertility treatments are categorised into two of the following groups on birth certificates: assisted reproductive technology (ART) fertility treatment (surgical egg removal; eg, in vitro fertilisation and gamete intrafallopian transfer) and non-ART fertility treatment (eg, medical treatment and intrauterine insemination). We compared the risk for CCHD in ART and non-ART fertility treatment groups with those infants whose mothers received no documented fertility treatment and were naturally conceived (NC).<bold>Results: </bold>Among 14 242 267 live births from 2011 to 2014, a total of 101 494 live births were in the ART and 81 242 resulted from non-ART fertility treatments. CCHD prevalence in ART, non-ART and NC groups were 393/100 892 (0.39%), 210/80 884 (0.26%) and 10 749/14 020 749 (0.08%), respectively. As compared with naturally conceiving infants, risk for CCHD was significantly higher among infants born in ART (adjusted relative risk (aRR) 2.4, 95% CI 2.1 to 2.7) and non-ART fertility treatment groups (aRR 1.9, 95% CI 1.6 to 2.2). Absolute risk increase in CCHD due to ART and non-ART treatments were 0.03% and 0.02%, respectively. A similar pattern was observed when the analysis was restricted to twins, newborns with birth weights under 1500 g and gestational age of less than 32 weeks.<bold>Conclusions: </bold>Our findings suggest an increased risk for CCHD in infants conceived after all types of infertility treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13556037
- Volume :
- 104
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Heart
- Publication Type :
- Academic Journal
- Accession number :
- 129525339
- Full Text :
- https://doi.org/10.1136/heartjnl-2017-312015