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Toxicities Associated with Docetaxel-Based Regimens in the Adjuvant Treatment of Early-Stage Breast Cancer: A Multicenter Prospective Real-Life Experience.
- Source :
- Breast Care; Apr2018, Vol. 13 Issue 2, p121-125, 5p, 4 Charts, 3 Graphs
- Publication Year :
- 2018
-
Abstract
- <bold><italic>Background:</italic></bold> The present study reports on the efficacy and safety of adjuvant docetaxel in real-life patients with early-stage breast cancer. <bold><italic>Methods:</italic></bold> This is a prospective, multicenter, post-marketing study that evaluates the efficacy and safety of docetaxel-based regimens in patients with early breast cancer treated between 2007 and 2012. <bold><italic>Results:</italic></bold> A total of 698 female breast cancer patients receiving adjuvant docetaxel-based regimens were included in this study. Docetaxel monotherapy was administered in 4.2%, whilst most patients received polychemotherapy. Non-hematological adverse events included skin reactions in 32.7% of the subjects. Multiple adverse events were reported and most commonly included asthenia (66.5%), alopecia (43.4%), and diarrhea (24.2%). It is noteworthy that no fatal toxicities occurred. Several hematological adverse events were reported during treatment, with anemia being the most common. <bold><italic>Conclusion:</italic></bold> The results of this real-life experience, characterized by a relatively large sample size and long follow-up, confirm that docetaxel is effective and well tolerated in early-stage breast cancer patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16613791
- Volume :
- 13
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Breast Care
- Publication Type :
- Academic Journal
- Accession number :
- 129466191
- Full Text :
- https://doi.org/10.1159/000481339