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Acid-base alterations in ESRD and effects of hemodialysis.
- Source :
- Seminars in Dialysis; May/Jun2018, Vol. 31 Issue 3, p226-235, 10p, 1 Graph
- Publication Year :
- 2018
-
Abstract
- Acid-base alterations in patients with kidney failure and on hemodialysis (HD) treatment contribute to (1) intradialytic hypercapnia and hypoxia, (2) hemodynamic instability and cardiac arrhythmia, (3) systemic inflammation, and (4) a number of associated electrolyte alterations including potentiating effects of hypokalemia, hypocalcemia and, chronically, soft-tissue and vascular calcification, imparting poor prognosis and mortality. This paper discusses acid-base regulation and pathogenesis of dysregulation in patients with kidney failure. Major organ and systemic effects of acid-base perturbations with a specific focus on kidney failure patients on HD are emphasized, and potential mitigating strategies proposed. The high rate of HD-related complications, specifically those that can be accounted for by rapid and steep acid-base perturbations imposed by HD treatment, attests to the pressing need for investigations to establish a better dialysis regimen. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08940959
- Volume :
- 31
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Seminars in Dialysis
- Publication Type :
- Academic Journal
- Accession number :
- 129426964
- Full Text :
- https://doi.org/10.1111/sdi.12659