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Antiplasmodial prenylated flavanonols from <italic>Tephrosia subtriflora</italic>.

Authors :
Muiva-Mutisya, Lois M.
Atilaw, Yoseph
Heydenreich, Matthias
Koch, Andreas
Akala, Hoseah M.
Cheruiyot, Agnes C.
Brown, Matthew L.
Irungu, Beatrice
Okalebo, Faith A.
Derese, Solomon
Mutai, Charles
Yenesew, Abiy
Source :
Natural Product Research; Jun2018, Vol. 32 Issue 12, p1407-1414, 8p
Publication Year :
2018

Abstract

The CH&lt;subscript&gt;2&lt;/subscript&gt;Cl&lt;subscript&gt;2&lt;/subscript&gt;/MeOH (1:1) extract of the aerial parts of &lt;italic&gt;Tephrosia subtriflora&lt;/italic&gt; afforded a new flavanonol, named subtriflavanonol (&lt;bold&gt;1&lt;/bold&gt;), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (&lt;bold&gt;2&lt;/bold&gt;) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound &lt;bold&gt;2&lt;/bold&gt; showed the highest activity against chloroquine-sensitive &lt;italic&gt; Plasmodium&#160;falciparum&lt;/italic&gt; reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC&lt;subscript&gt;50&lt;/subscript&gt; values 1.4-4.6&#160;μM without significant cytotoxicity against Vero and HEp2 cell lines (IC&lt;subscript&gt;50&lt;/subscript&gt;&#160;&gt;&#160;100&#160;μM). The new compound (&lt;bold&gt;1&lt;/bold&gt;) showed weak antiplasmodial activity, IC&lt;subscript&gt;50&lt;/subscript&gt; 12.5-24.2&#160;μM, but also showed selective anticancer activity against HEp2 cell line (CC&lt;subscript&gt;50&lt;/subscript&gt; 16.9&#160;μM). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14786419
Volume :
32
Issue :
12
Database :
Complementary Index
Journal :
Natural Product Research
Publication Type :
Academic Journal
Accession number :
129302150
Full Text :
https://doi.org/10.1080/14786419.2017.1353510