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Antiplasmodial prenylated flavanonols from <italic>Tephrosia subtriflora</italic>.
- Source :
- Natural Product Research; Jun2018, Vol. 32 Issue 12, p1407-1414, 8p
- Publication Year :
- 2018
-
Abstract
- The CH<subscript>2</subscript>Cl<subscript>2</subscript>/MeOH (1:1) extract of the aerial parts of <italic>Tephrosia subtriflora</italic> afforded a new flavanonol, named subtriflavanonol (<bold>1</bold>), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (<bold>2</bold>) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound <bold>2</bold> showed the highest activity against chloroquine-sensitive <italic> Plasmodium falciparum</italic> reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC<subscript>50</subscript> values 1.4-4.6 μM without significant cytotoxicity against Vero and HEp2 cell lines (IC<subscript>50</subscript> > 100 μM). The new compound (<bold>1</bold>) showed weak antiplasmodial activity, IC<subscript>50</subscript> 12.5-24.2 μM, but also showed selective anticancer activity against HEp2 cell line (CC<subscript>50</subscript> 16.9 μM). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 32
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 129302150
- Full Text :
- https://doi.org/10.1080/14786419.2017.1353510