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Determination of the Primary Structure of a Mouse IgG2a Immunoglobulin: Amino-Acid Sequence of the Fc Fragment.
- Source :
- European Journal of Biochemistry; Apr74 Part 2, Vol. 43 Issue 3, p423-435, 13p
- Publication Year :
- 1974
-
Abstract
- The amino-acid sequence of the Fe fragment of a mouse monoclonal IgG2a molecule is presented. With the exception of one deletion, this region possesses the same length as that of the human γl chain or that of the rabbit γ chain. Identities between the Fc fragments of 3 animal species (human, mouse and rabbit) average 50% and are markedly more pronounced for the C<subscript>H</subscript>2 domain than for the C<subscript>H</subscript>3 domain, observation which is in agreement with an independent evolution of each homology region. Strikingly, the degree of conservation of the V<subscript>H</subscript> region is of the same order of magnitude as that observed for the Fc fragment. This parallelism in evolution is discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOCHEMISTRY
IMMUNOGLOBULINS
AMINO acids
MONOCLONAL antibodies
HOMOLOGY (Biology)
Subjects
Details
- Language :
- English
- ISSN :
- 00142956
- Volume :
- 43
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- European Journal of Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 12922388
- Full Text :
- https://doi.org/10.1111/j.1432-1033.1974.tb03428.x